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GXCX-type high-performance chromatography column
Detailed description
product description
GXCX high-efficiency chromatography column is developed by our company,
which is a high-efficiency chromatographic device with medium-pressure
axial linear flow technology.It is equipped with 0.5 type 600 series
specifications of 10 varieties, with separation speed, short working
time, high purification efficiency, (Chinese medicine, pesticide)
natural plant, marine biology, biochemical products, genetic engineering
and other industries (chemical, food, pharmaceuticals, etc.), the use
of a wide range of advantages, easy to operate, the application of a
wide range of advantages.Use the difficult to separate materials used to
improve work efficiency, are widely used.
in view of our company's technical strength and rich production
experience, in recent years, combined with the status quo extraction and
separation of production technology and user demand, in order to be a
reasonable choice selection of technical solutions and sophisticated
equipment, but also to ensure high quality and reliable Of the
manufacturing quality. My company at the same time in the tooling
technology, means of detection and product design, and other aspects of
continuous improvement and maturing, has made gratifying achievements
gratifying, the level of technology and product quality in the country
are in a leading position.
Equipment characteristics
GXCX high-performance chromatography devices are composed of the main
components such as the solvent-liquid tank, the pressure pump (or
nitrogen), the multi-stage switching solenoid valve, the control valve,
the controller, the packing (stationary phase) column and the detector.
technology are as follows:
① the feed tank
. tank to accept material feed, eluent, cleaning agents special
containers were assembled frequency magnetic stirring and without
stirring two models, in order to achieve continuous operation and
efficient quick change function features.
② the pressure pump
pressure pump is used to feed the chromatography column, elution,
cleaning supplying the working fluid to the working pressure is high,
low traffic, good stability, not to destroy its active substance and the
advantages of no leakage of liquid. for this reason the configuration
of the pump selection is very important, the ability to work in the
separation process, and the importance of having the shape of the pump.
③ multi-stage solenoid valve system
when the material feed work When the shift cleaning agent system, the
application of manual and automatic two technical forms, to achieve the
entire system piping connections, switching the exact purpose of the
technology, the application of automatic technology, can replace the
cumbersome manual operation improve the efficiency and reliability
without leakage of the solvent to make the machine more compact and to
work in unison.
④ controller
control product is the command center of the whole work, in front of the
controller is equipped with highly efficient micro static mixer , The
pre-filter, in addition to bubble. In order to ensure a balanced
distribution of materials and eluent effective mixing, the controller
plays a key role, the controller at the same time the pressure pump,
solution flow, flow more effective protection and regulation.
⑤ true material (stationary phase) column
mechanism cylinder design, precision manufacturing, guide the rational
distribution of fluid and precise filtration area calculations, and can
achieve high-speed linear fluid flow rate is to determine the success of
the separation The key technology.To this end our company brings
together the international advanced technology to update the design of
the column structure to successfully solve the rotation of the cylinder
180 ° operability, so that loading and unloading filler is more
convenient.
⑥ detector
according to varying process conditions, or the selection can be
recommended for users equipped with various detectors in order to
isolate the detection and tracking of all process equipment records.
Efficient chromatography apparatus have the following technical
characteristics and use of the advantages of conventional chromatography
columns can not be compared.
1. facilitate the original process on the basis of linear amplification,
improve student efficiency, shorten time to market production Lu
drainage.
2. at low flow rates can be linear, and a large flow rate, use, improve
production efficiency, the flow rate may be increased by 5 times -15
times.
3. to improve packing efficiency, the unit volume of the amount of
filler to achieve the highest binding capacity, especially in industrial
production .
4. reduce separation time, so that the products have high activity and yield, with significant economy;
5. Replace the filler may be cylinder rotating 180 °, easy disassembly
is convenient, easy to operate, reduce cross-contamination, in line with
the GMP process requirements.
7. the bed height is moderate, to ensure low back pressure.
8. packing (stationary phase) column, no dead volume.
can achieve operating under nitrogen pressure and high-pressure pump
conditions, under normal circumstances, 0.5L-10L of column options with
pressurized nitrogen gas, saving investment, more than 50 high-pressure
pump can be used, to improve work efficiency.
according to the actual demand, the process conditions can be column and
other ancillary equipment to optimize the combination to achieve the
best investment results .
Technical Parameters
GXCX-type high-performance chromatography column basic parameters as follows: |
Column effective volume L | diameterØ=mm | heighth=mm | diameter height ratio (low, high) | working pressure Mpa | Remarks |
0.5 | 35 | 750 | 1:20 1:30 | 0.3 | Mobile phase transport - nitrogen |
1 | 50 | 1000 | 1:1 1:20 | 0.3 | Mobile phase transport - nitrogen |
10 | 100 | 1300 | 1:1 1:20 | 0.3 | Mobile phase transport - Nitrogen or pump |
50 | 150 | 1800 | 1:0.5 1:20 | 0.3 | Mobile phase transport - Nitrogen or pump |
100 | 200 | 2000 | 1:4 1:20 | 0.3 | Mobile phase transfer - pump |
200 | 250 | 3000 | 1:6 1:20 | 0.3 | Mobile phase transfer - pump |
400 | 300 | 3000 | 1:10 1:20 | 0.3 | Mobile phase transfer - pump |
600 | 300 | 3000 | 1:6 1:10 | 0.3 | Mobile phase transfer - pump |
Note: 1.
Material selection according to the process requirements, the use of
stainless steel SUS304, SS316L. Or coating nickel-phosphorus. 2. Users
have special requirements can be designed and manufactured.
It is widely used in the fields of medicine, medicine, food,
fine chemicals, natural plants, marine biology, biochemical products,
genetic engineering and so on, with good usability and separation
effect.
Applications The following table shows the usage
industry | Typical material | industry | Typical material | industry | Typical material |
medicine | Yew | Chemical industry | Monoclonal antibodies | food | Capsaicin |
Alkaloids | Natural pigments | Lycopene | |||
Cucurbitacin | Inositol | Natural Vitamin E | |||
Flavonoid glycosides | Chlorophyll | carbohydrate | |||
Coumarin | Fluorescent whitening agent | Phosphate | |||
Antibiotics | / RTI & gt; | Cholesterol | |||
Pharmaceutical intermediates category | Ethyl sulfone sulfuric acid | spices | Corn oil | ||
Biological Engineering | Core sugar nucleic acid | pesticide | Avermectin | Oxidized terpenes | |
Human white IL-2 concentrated drug | Carbamates | Lime type | |||
Interference | Pyrethrin series | Triterpene acids | |||
Proteins | Herbicides | Leaving alcohol compounds |
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